Compound prescriptions, also known as “synergistic,” “dynamic,” or “composite” prescriptions, are prescriptions that include two or more medications. According to the National Library of Medicine, compound prescriptions may improve patient compliance and reduce the risk of drug interactions. However, the American Academy of Family Physicians notes that there is limited evidence to support the use of compound prescriptions. The American College of Physicians does not recommend the use of compound prescriptions for the treatment of any condition.
In addition, the Centers for Disease Control and Prevention reports that compound prescriptions are associated with an increased risk of medication errors. As a result, the American Academy of Family Physicians recommends that physicians only prescribe compound prescriptions when they are confident that the medications will work together and will not lead to an increased risk of adverse effects.
